Side Effects of Oral Acne DrugsOral acne drugs treat the problem from inside your body by subduing hormones that boost oil production. These consist of prescription antibiotics such as tetracycline (Tetracin, Tetracap) and minocycline (Solodyn, Minocin) and the pill called spironolactone (Aldactone).Some oral drugs are offered over-the-counter whil